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Elderly depression, what should I pay attention to when using sertraline?

Time:2022-12-03 14:31:02 source:psychiatricethics.com author:Emergency treatment Read:846次
Elderly depression, what should I pay attention to when using sertraline?

A friend told Hua Zi that after his father suffered from a cerebral infarction, his limbs were inflexible, he sighed every day, and his mental state was particularly poor. I went to the doctor, said it was depression, and asked me to take a drug called sertraline. Is there anything I need to pay attention to? Hua Zi said that many elderly people who suffer from chronic diseases such as coronary heart disease and stroke think that it is an incurable "terminal illness", which makes them prone to pessimism, despair, and even depression. Sertraline is a treatment for elderly depression. of commonly used drugs.

First, what is the role of sertraline

Depression is a mental illness, but when it occurs, the human body’s physiological related changes will also occur. The main manifestation is the decrease in the secretion of the neurotransmitter 5-hydroxytryptamine (5-HT) in the central nervous system, which reduces the nerve excitability. Sertraline is a selective serotonin reuptake inhibitor (SSRI), which increases the level of serotonin in the synaptic cleft and increases neural excitability. Sertraline can improve symptoms related to depression, as well as symptoms such as obsessive-compulsive disorder, anxiety, panic attacks, and menstrual irritability in women.

Second, how much and how long to take sertraline

The recommended dose of sertraline starts from 50 mg per day. If the dose needs to be increased, adjust the interval between the doses It should not be shorter than 1 week, in increments of 50 mg each time, up to a maximum dose of 200 mg per day. Usually you can see the effect after 1 week of taking the medicine, but the best effect takes 2 to 4 weeks to achieve, and it may take longer for the treatment of obsessive-compulsive disorder. The treatment of depression usually needs to last for more than 6 months. When taking sertraline for a long time, the dose should be adjusted according to the efficacy and maintained at the lowest effective therapeutic dose. The maintenance dose is between 25mg and 200mg per day.

Three, what to pay attention to when taking sertraline

When using sertraline, a few people will experience gastrointestinal adverse reactions such as dry mouth, nausea, diarrhea, constipation, etc. , usually mild, can be tolerated without affecting medication. Central nervous system adverse reactions include headache, drowsiness, insomnia and other reactions. People with drowsiness can take the medicine before going to bed; people with insomnia can take the medicine in the morning to reduce the impact. Common adverse reactions usually resolve and disappear after 1 to 2 weeks of medication. There are very few male patients who may experience adverse reactions of ejaculation disorder (delayed) after taking the drug, but it has a certain improvement effect on patients with premature ejaculation. There are also some uncommon adverse reactions. Elderly people with severe dietary salt restriction may experience hyponatremia; may increase bleeding tendency; increased intraocular pressure (use with caution in glaucoma). If an allergic reaction occurs, it should be disabled; if epilepsy symptoms occur during treatment, the drug should be discontinued immediately; the dose of hepatic insufficiency should be reduced.

Fourth, sertraline is not effective for everyone

The causes of depression are complex, and different people have different sensitivity to drugs. Sertraline treatment The effective rate is about 70%, and some patients may have no effect, and drug resistance may occur during long-term medication, resulting in treatment failure. When taking the medicine, follow the doctor's advice and take the medicine in a sufficient amount and for a full course of treatment. After taking the drug, if the doctor confirms that the depressive symptoms have not improved, you can switch to other types of antidepressant drugs under the guidance of the doctor. After a sufficient course of sertraline treatment, the dose should be gradually reduced and discontinued. If the drug is suddenly stopped, withdrawal reactions may occur, or the disease may recur. It usually takes several weeks or months to stop the drug. To sum up, sertraline for the treatment of depression has a long clinical application and relatively few adverse reactions, so it is often used in the treatment of depression in the elderly. When taking medication, pay attention to the slow increase and decrease of the drug dose, and maintain a sufficient amount of medication for a full course of treatment. If you find a problem while taking the medicine, you should communicate with your doctor or pharmacist more. I am Huazi, a pharmacist. Welcome to follow me and share more health knowledge.

(责任编辑:Prevent anxiety)

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