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World Alzheimer's Day: Science tackles 'the eraser in the mind'

Time:2022-12-03 05:18:53 source:psychiatricethics.com author:Mental disorder Read:191次
World Alzheimer's Day: Science tackles 'the eraser in the mind'

September 21st is World Alzheimer's Day. Alzheimer's disease is a progressive neurodegenerative disease with insidious onset, which imposes a heavy burden on families and society. However, many people and even some doctors still have misunderstandings about the disease in life, resulting in a very low rate of Alzheimer's disease visits and treatment in my country. So what is Alzheimer's disease? What are the common misconceptions about Alzheimer's disease? How to treat? Hear what the experts have to say.

What is Alzheimer's disease?

Alzheimer's disease is a progressive neurodegenerative disease with insidious onset, clinically characterized by memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction and personality It is characterized by generalized dementia such as changes in behavior and behavior. Those with onset before the age of 65 are called early-onset dementia, and those with onset after the age of 65 are called late-onset dementia. For people over the age of 65, the incidence doubles for every 5 years of age. The elderly population over the age of 85 has reached one-third. Risk factors exist in people's life, and different life stages have different important risk factors. When you are older, your family members have relatives (such as parents, siblings, etc.) who have Alzheimer's disease, and suffering from diseases, including but not limited to thyroid disease, diabetes, cardiovascular disease, epilepsy, etc., are all causes of Alzheimer's disease Important risk factors for Haimer's disease. The general public awareness of Alzheimer's disease is insufficient. The current status is that the level of cognition is low, the rate of doctor visits is low, and the proportion of receiving treatment is even lower, with only 5% receiving treatment. 85% of the patients' families believe that the memory loss of the elderly is a natural aging process, and no treatment is necessary, thus delaying medical treatment. It is urgent to raise the awareness of Alzheimer's disease in the whole society, improve the social and living environment of patients, and let patients have a dignified and quality life. Alzheimer's disease is irreversible, and the effect of early detection and early treatment is far greater than the effect of later detection and treatment.

What are the common misconceptions about Alzheimer's disease?

Most family members believe that it is natural for the elderly to experience memory loss as they get older, and it is normal that they cannot keep their minds sharp. Some family members think that Alzheimer's disease is just like other diseases, just go to the hospital to take medicine and get injections. There are also many family members who will ask if the treatment is still ineffective after 1 month of treatment, whether the diagnosis is wrong, and whether the medication is still effective? In fact, patients not only need to go to the hospital for treatment, but also need the active cooperation of patients and their families. Home care is very important. In addition, treatment is a long-term process. In addition to drugs, it also requires rehabilitation, exercise, reasonable diet, stress management and other brain-healthy lifestyles to restore some functions.

Is Alzheimer's Disease Curable? Will it affect lifespan?

We cannot avoid aging, nor can we cure Alzheimer's disease at this stage. However, we can give the elderly more care and let them spend this "longest love farewell" with more dignity and dignity. Alzheimer's disease eventually manifests as disability and dementia. In the late stage, progressive cognitive impairment and aggravation of psycho-behavioral symptoms, followed by emotional indifference, inconstant crying and laughing, and loss of speech ability, so that simple life tasks cannot be completed, gradually incapacitated, and bedridden all day long. Late stage is often complicated by systemic diseases, such as pulmonary infection, urinary tract infection, pressure ulcers, systemic multiple organ failure, etc. In severe cases, it is life-threatening. For families with Alzheimer's disease, comfort alone is not enough, we need more care resources and improve the family's care capacity. The psycho-behavioral symptoms of Alzheimer's disease are one of the most important reasons for patients to be admitted to hospital, because they refuse to be cared for, are difficult to manage, and significantly increase the care burden of their families. Current anti-dementia drugs can achieve 30-40% efficacy. Through the risk-benefit assessment of professional doctors, after active treatment, the quality of life and social function of patients can be improved to a certain extent, and the progression of dementia can also be delayed. Especially in recent years, with the development of stem cells and regenerative medicine technology, new treatment ideas have been developed for the treatment of Alzheimer's disease. In some clinical studies, stem cell transplantation has been used to restore degenerated neuronal networks and cognitive function, stem cells can be used as a cell delivery system, using paracrine mechanisms for repair purposes; or using stem cells to differentiate and promote neural circuit regeneration. for the purpose of treatment. Recently, on the basis of preclinical research, Wu Jingwen's research group conducted a free clinical exploratory study on 5 AD subjects by instilling neural stem cells through the nasal cavity. Preliminary studies have confirmed that the treatment is safe and effective. First, none of the AD subjects involved in the study showed any adverse reactions; at the same time, after 3 months of observation and follow-up, the cognitive function of the 5 AD subjects was improved to varying degrees. The main manifestations are that memory and orientation have been significantly improved; language expression ability has improved; paranoid, stubborn and other personalities have transformed into obedience and obedience; irritable and irritable have transformed into quiet and peaceful; from sitting all day to lively and active ; Somatic pain symptoms disappeared in individual AD subjects. Although the above clinical studies have achieved certain curative effects, further follow-up and summary are needed due to the limited number of samples and the short time of experimental observation. We believe that with the continuous expansion of the AD subject population in the future, the experts of the research group will obtain more detailed clinical research data. Most scientists believe that stem cell therapy is the current research hotspot in the treatment of Alzheimer's disease, and it is also the current and future treatment direction, and it is also the most likely to become a powerful weapon against brain health killers. We believe that with the medical

to our readers:

Hello, I am Dr. Wu Jingwen, and I would like to thank you all for reading my article. If you have a disease and consult me, you can contact me through the platform "private message". You can also leave a message under the article, and I will answer your questions as soon as possible.

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