Time：2023-03-28 01:15:28 source：psychiatricethics.com author：Relax Read：765次

After taking statin, blood lipids are normal, when can I stop taking it?

Many friends have left messages to Hua Zi, asking about the same thing, suffering from hyperlipidemia, after taking statins, blood lipids have dropped to normal, so how long should statins be taken, and when can I stop? Hua Zi told them that hyperlipidemia is a metabolic disorder syndrome. If the drug is stopped, blood lipids will rise again. And for people at risk of cardiovascular and cerebrovascular diseases, statins can not only reduce blood lipids, but also prevent diseases, and long-term medication is required to exert their efficacy.

I. What will high blood lipids bring?

There are many components in human blood lipids, among which low-density lipoprotein cholesterol (LDL-C) is the main source of cardiovascular and cerebrovascular diseases key indicators. Its level is closely related to the incidence of coronary heart disease, myocardial infarction, cerebral infarction and other diseases. Controlling LDL-C levels is an important way to prevent cardiovascular and cerebrovascular diseases. There are also triglycerides (TG) in blood lipids, which also increase the risk of cardiovascular and cerebrovascular diseases, but relatively speaking, the risk is not as high as LDL-C. There is also lipoprotein (a) - LP(a) in blood lipids, which is similar in risk to LDL-C, but there is currently no good intervention for LP(a). Therefore, the current treatment for hyperlipidemia is mainly to control LDL-C levels.

Second, why does cholesterol rise

Many people think that rising cholesterol means eating too much oil and too greasy. Although fatty foods can increase cholesterol, it can only affect 30% at most. 70% of cholesterol in the human body is synthesized by itself. Therefore, there are many people who are vegan diets, and their blood lipids will also exceed the standard. Most people's hyperlipidemia is primary, and no specific cause can be found at the current medical level. Hyperlipidemia is a metabolic disorder syndrome, which is called "three high" chronic diseases together with hypertension and diabetes. It can only be controlled by drugs, and there is no cure.

Three, the role of statins

to control LDL-C levels, statins are the most commonly used drugs. Statins can inhibit the synthase of cholesterol, reduce cholesterol in the blood, and directly reduce the level of LDL-C, which can reduce the risk of cardiovascular and cerebrovascular diseases. For people with atherosclerosis, the biggest risk is the rupture of atherosclerotic plaques, causing platelets to aggregate to form thrombus, which can cause cerebral infarction and myocardial infarction. While statins reduce LDL-C, they can also increase the stability of plaques. When used for a long time, they can also reverse plaques, reduce the degree of arterial stenosis, and prevent plaque rupture. Good preventive effect.

4. When can statins be stopped

Many people are concerned, when can statins be stopped? Stopping statins requires one of two conditions: the first is the achievement of the drug goal, and the second is the occurrence of serious adverse reactions. Lowering LDL-C and preventing cardiovascular and cerebrovascular diseases are the goals of statins. Most people's LDL-C can drop to normal levels after taking the drug, but this is the result of the drug, and it will rise again when the drug is stopped, so continuous medication is needed to control blood lipids. The goal of medication for a small number of people is simply to lower blood lipids. With lifestyle interventions such as diet control, increased exercise, and weight loss, after blood lipids return to normal, they can try to stop the medication. People with atherosclerosis can only see plaque reversal after taking the drug for more than 6 months at the earliest. In most people, it takes 2 to 4 years of continuous medication to achieve plaque reversal. According to the current research, the longer the statin is taken, the greater the benefit, so it is not recommended to stop the drug prematurely, and it should be taken as long as possible. During statin administration, if abnormal liver function occurs, transaminases (AST, ALT) increase to more than 3 times the normal value; or muscle soreness, fatigue, and creatine kinase (CK) level increase to more than 5 times the normal value , it is recommended to stop the drug and see a doctor, and under the guidance of a doctor, change the drug to take intervention measures. To sum up, after taking statins, blood lipids are only temporarily controlled to normal, which does not mean that the disease is cured. It is not recommended to stop taking statins as long as there are no serious adverse reactions. The longer the drug is used, the better the preventive effect on cardiovascular and cerebrovascular diseases. The medicine should be taken under the guidance of a doctor. If you have any doubts about the medicine, please consult your doctor or pharmacist. I am Huazi, a pharmacist. Welcome to follow me and share more health knowledge.

(责任编辑：Mental disorder)

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