Time：2023-03-28 00:21:48 source：psychiatricethics.com author：Relax Read：949次

Xuzhou Depression: Is Depression Because of "High Pressure"?

Xuzhou Mental Health Service Station: In fact, people who are "excessive stress" have a higher risk of depression. Stress can come from chronic stress states, such as study and work stress, financial stress, etc. , or from acute stress, such as the unexpected departure of a loved one, a traffic accident, etc. But the causes of depression are far from simple. To this day, many scholars around the world are working to find a clearer cause of depression so that treatments can be more targeted. Many factors have been found to be associated with depression. Genetic factors Depression is considered to be a polygenic genetic disease, and its occurrence is closely related to genetic quality. About 40% to 70% of patients have a genetic predisposition, that is, nearly half or more have a family history of depression. Research on neurobiochemical changes has shown that the content of neurotransmitters such as serotonin and norepinephrine in patients with depression is different from that of normal people, and there are disorders. Therefore, the serotonin (5-HT) and norepinephrine (ne) hypothesis was proposed. Neuroendocrine dysfunction Many studies have found abnormalities in neuroendocrine axes in patients with depression, such as the hypothalamic-pituitary-adrenal axis (HPA) and the hypothalamic-pituitary-thyroid axis (HPT). In general, the neuroendocrine axis is a system that regulates the body's endocrine system by sending "commands" to the brain layer by layer. Electrophysiological abnormal sleep EEG studies have found that the sleep of patients with depression has the following changes: total sleep time is reduced, and the number of awakenings is increased; 30% of patients with depression have abnormal EEG; VEP latency is short. Before drug treatment, the right VEP was greater than the left. The amplitude of somatosensory evoked potentials recovered slowly, and the latency recovered quickly. The CNV amplitude was low and the negative potential was prolonged. Neuroimaging Abnormal Structural Imaging Studies have focused on abnormalities in neural circuits associated with emotion regulation. It is proposed that the most significant brain changes in patients with depression involve the medial prefrontal cortex, anterior cingulate gyrus, amygdala, hippocampus, thalamus, and hypothalamus, and recent academic discussions have focused on the prefrontal cortex and limbic system and these functional abnormalities. Psychological, social and environmental factors, marital status, financial status; stressful life events, especially major conflicts (sudden death of a loved one, lovelorn, heavy property losses) or life events lasting more than 2-3 months, can all become the cause of depression direct cause. Widowhood is the stressor most closely associated with depression.

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