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Delirium Treatment

Time:2022-09-27 15:58:34 author:Public activities Read:755次
Delirium Treatment

Targeted prevention of delirium-prone populations may reduce the incidence of delirium. In addition to age, delirium is related to many factors, and finding predictors of delirium has become a research hotspot. Studies have found that the more ApoE4 alleles are carried, the more severe the delirium; imaging data may also provide some clues for predicting delirium. Delirium treatment begins with addressing the trigger. Hypoproteinemia, electrolyte imbalance, abnormal blood sugar, abnormal blood gas, elevated serum creatinine, infection, etc., as well as some of the conditions mentioned above, are all causes of delirium, and it is very important to actively treat these conditions. Treatment of delirium in older adults includes both nonpharmacological and pharmacological interventions. HELP (Hospital Elder LifeProgram) is a collaborative effort between trained volunteers and an interdisciplinary geriatric health care team that includes reorientation, early mobilization, non-pharmacological improvements in sleep cycles, improved audiovisual and cognitive function, and encouragement to eat. . Drug therapy is mainly used when the patient has serious situations such as agitation and endangers the safety of themselves or others. Antipsychotic drugs, such as haloperidol, olanzapine, quetiapine, etc., can be used, but whether these drugs can shorten the duration of delirium The timing is still controversial; narcotic analgesia has a certain benefit in reducing delirium in patients on mechanical ventilation, ICU, and perioperative period. It should be noted that psychotropic and sedative-hypnotic use may convert excitatory delirium to depressive delirium, which tends to have a worse prognosis. The melatonin receptor agonist Ramelteon (Ramelteon) is a drug for the treatment of insomnia, and clinical trials have found that it has a good effect on the prevention of delirium. As for cholinesterase inhibitors such as donepezil, cabalatine, etc. in clinical studies of delirium, the results are uncertain.

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